Influence of Intraoperative Blood Loss on Tumor Recurrence after Surgical Resection in Hepatocellular Carcinoma

The high incidence of hepatocellular carcinoma (HCC) recurrence after surgical resection worsens the long-term prognosis. Besides tumor-related factors, operative factors such as perioperative blood transfusion have been reported to be related HCC recurrence. However, excessive intraoperative loss (IBL) always necessitates transfusion, where IBL and may influence oncologic outcomes. We enrolled 142 patients with newly diagnosed single who underwent hepatic between March 2010 July 2021. Patients were stratified into two groups by volume: Group A (IBL ≥ 700 mL, n = 47) B < 95). clinic–pathologic findings, outcomes, cumulative probability tumor overall survival compared groups. In study, increased (1351 ± 698 vs. 354 166, p 0.001) (63.8% 6.3%, common in A, a greater (p poor 0.017) those B. Preoperative albumin (hazard ratio [HR], 0.471; 95% confidence interval [CI], 0.244–0.907, 0.024), microvascular invasion (HR, 2.616; CI, 1.298–5.273; 0.007), mL 2.325; 1.202–4.497; 0.012) significant risk for HCC. conclusion, efforts minimize during are important improving prognosis patients.